Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression\r\nof disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous\r\ncellular, tissue, and animal models have been exploited to probe this host-pathogen interaction. Here we review the range of\r\nexperimental models that are available for cryptococcosis research and compare the relative advantages and limitations of the\r\ndifferent systems.
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